反应详情

温度

115 °C

A mixture of isatoic anhydride (4.00 g, 24.5 mmol) and 4-bromoaniline (4.20 g, 24.5 mmol) in anhydrous DMF (30 mL) was stirred at 115° C. for 60 hours under nitrogen. DMF was removed under vacuum and the residue was partitioned between ethyl acetate (75 mL) and water (75 mL). The organic phase was separated, washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated under vacuum to give crude 2-amino-N-(4-bromophenyl)benzamide. Yield: 1.00 g (14%).

1. customDMF was removed under vacuum
2. customthe residue was partitioned between ethyl acetate (75 mL) and water (75 mL)
3. customThe organic phase was separated
4. washwashed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. customThe solvent was evaporated under vacuum