反应详情

温度

130 °C

A mixture of 8-chloro-1H-benzo[d][1,3]oxazine-2,4-dione (0.80 g, 4.05 mmol) and 4-bromoaniline (0.70 g, 4.05 mmol) with anhydrous DMF (1 mL) was heated at 130° C. for 2 hours. Water (50 mL) was added, and the product was extracted with ethyl acetate (200 mL). The organic phase was separated, washed with water (100 mL), brine (100 mL) and dried over anhydrous Na2SO4. The solvent was evaporated in vacuo, and the crude material was washed with ether, to give 2-amino-N-(4-bromophenyl)-3-chlorobenzamide as an off-white solid. Yield 1.17 g (89%).

1. extractionthe product was extracted with ethyl acetate (200 mL)
2. customThe organic phase was separated
3. washwashed with water (100 mL), brine (100 mL)
4. dry with materialdried over anhydrous Na2SO4
5. customThe solvent was evaporated in vacuo
6. washthe crude material was washed with ether