Methyl morpholine oxide → HCID 86659816, compound

Participants

Reaction Steps

(6-((tetrahydro-2H-pyran-2-yloxy)methyl)pyridin-3-yl)methanol (1.3 g, 6.0 mmol) was dissolved in CH2Cl2 (80 mL) and NMO (0.846 g, 7.2 mmol) and TPAP (0.210 g, 0.6 mmol) were added. After stirring at room temperature for 20 minutes, the reaction mixture was filtered through Celite®, and the filtrate was concentrated. Purification of the residue by flash chromatography on silica gel, eluting with 30% ethyl acetate/heptane to 75% ethyl acetate/heptane, afforded 6-((tetrahydro-2H-pyran-2-yloxy)methyl)nicotinaldehyde as a yellow oil (0.560 g, 42%).

Provenance & Evidence