Hydrochloric Acid → HCID 66978310, compound

HRID 1846425Notes

Reaction equation

HRID 1846425 reaction equation
[OH-].[Na+].[CH3:3][C:4]1[C:9]2[NH:10][C:11](=[O:13])[O:12][C:8]=2[CH:7]=[C:6]([C:14]([O:16]C)=[O:15])[CH:5]=1.O.Cl>CO>[CH3:3][C:4]1[C:9]2[NH:10][C:11](=[O:13])[O:12][C:8]=2[CH:7]=[C:6]([C:14]([OH:16])=[O:15])[CH:5]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium Hydroxide2×HCID 66978222HCID 66978222, compound

Product 1

HCID 66978310HCID 66978310, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

20 mL 4N aqueous sodium hydroxide solution were added to 5.00 g (24.1 mmol) methyl 4-methyl-2-oxo-2,3-dihydro-benzoxazole-6-carboxylate in 50 mL MeOH and the mixture was stirred for 24 h at RT. Then 10 mL of 4N aqueous sodium hydroxide solution were added and the mixture was stirred for a further 8 h at RT. Then the MeOH was eliminated i.vac., water was added and while cooling with ice the mixture was acidified with conc. hydrochloric acid solution until a precipitate formed. This was suction filtered, washed with water and dried i. vac.

Workup

  1. stirringthe mixture was stirred for a further 8 h at RT
  2. temperaturewhile cooling with ice the mixture
  3. customformed
  4. filtrationThis was suction filtered
  5. washwashed with water
  6. customdried i

Sources & evidence

ORD record
ord-ae71162692be45d9ae93a4fbe618402b
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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