HCID 5135648, compound → HCID 66978206, compound

HRID 1846429Notes

Reaction equation

HRID 1846429 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([N+:11]([O-])=O)[C:3]=1[NH:14][C:15](=[O:17])[CH3:16]>[Pd].CO>[NH2:11][C:4]1[CH:5]=[C:6]([NH2:8])[CH:7]=[C:2]([CH3:1])[C:3]=1[NH:14][C:15](=[O:17])[CH3:16]

Participants

4

Reactant 1

HCID 5135648HCID 5135648, compound

Product 1

HCID 66978206HCID 66978206, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 45.0 g (0.188 mol) N-(2-methyl-4,6-dinitro-phenyl)-acetamide and 4.50 g palladium on charcoal (Pd/C 10%) in 1.400 L methanol was hydrogenated for 2 h at RT under a hydrogen atmosphere. The catalyst was removed by suction filtering and the filtrate was evaporated to dryness i.vac. The residue was triturated in diethyl ether, suction filtered and dried. The crude product obtained was used directly for the next step.

Workup

  1. customThe catalyst was removed by suction
  2. filtrationfiltering
  3. customthe filtrate was evaporated to dryness i.vac
  4. customThe residue was triturated in diethyl ether
  5. filtrationsuction filtered
  6. customdried

Sources & evidence

ORD record
ord-90a53d51327c44f3876cf8767bc0d448
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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