4,6-Dichloropyrimidine → HCID 178432264, compound

HRID 1846431Notes

Reaction equation

HRID 1846431 reaction equation
Cl.[CH3:2][C:3]1[NH:4][C:5]2[CH:11]=[C:10]([NH2:12])[CH:9]=[C:8]([CH3:13])[C:6]=2[N:7]=1.[Cl:14][C:15]1[CH:20]=[C:19](Cl)[N:18]=[CH:17][N:16]=1>C(O)CCC>[Cl:14][C:15]1[N:16]=[CH:17][N:18]=[C:19]([NH:12][C:10]2[CH:9]=[C:8]([CH3:13])[C:6]3[NH:7][C:3]([CH3:2])=[N:4][C:5]=3[CH:11]=2)[CH:20]=1

Participants

4

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 66978193HCID 66978193, compound

Product 1

HCID 178432264HCID 178432264, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Under a nitrogen atmosphere 3.00 g (15.2 mmol) 2,7-dimethyl-benzimidazol-5-ylamine-hydrochloride, 2.30 g (15.4 mmol) 4,6-dichloropyrimidine and 6.50 mL (47.0 mmol) TEA in 15 mL 1-butanol were stirred for 3 h at 100° C. After cooling to RT the reaction mixture was evaporated down, the residue was stirred in DCM and the precipitate formed was suction filtered and dried.

Workup

  1. customwas evaporated down
  2. customthe precipitate formed
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-6d34872ac91f41838d38dc0fc09708ea
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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