4,6-Dichloropyrimidine → HCID 178432264, compound

Participants

Reaction Steps

Under a nitrogen atmosphere 3.00 g (15.2 mmol) 2,7-dimethyl-benzimidazol-5-ylamine-hydrochloride, 2.30 g (15.4 mmol) 4,6-dichloropyrimidine and 6.50 mL (47.0 mmol) TEA in 15 mL 1-butanol were stirred for 3 h at 100° C. After cooling to RT the reaction mixture was evaporated down, the residue was stirred in DCM and the precipitate formed was suction filtered and dried.

Provenance & Evidence