Trifluoroacetic acid → HCID 66978249, compound

HRID 1846434Notes

Reaction equation

HRID 1846434 reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][N:9]1[C:13]2[C:14]([CH3:26])=[CH:15][C:16]([NH:18]C(=O)OC(C)(C)C)=[CH:17][C:12]=2[O:11][C:10]1=[O:27]>C(Cl)Cl>[NH2:18][C:16]1[CH:15]=[C:14]([CH3:26])[C:13]2[N:9]([CH3:8])[C:10](=[O:27])[O:11][C:12]=2[CH:17]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67126926HCID 67126926, compound

Product 1

HCID 66978249HCID 66978249, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

500 μL (6.58 mmol) TFA were added to 500 mg (1.80 mmol) tert-butyl (3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-carbamate in 10 mL DCM and the mixture was stirred for 1.5 h at RT. Then the reaction mixture was evaporated down, the residue was made alkaline and extracted with DCM. The organic phase was dried on sodium sulphate, filtered and evaporated down.

Workup

  1. customThen the reaction mixture was evaporated down
  2. extractionextracted with DCM
  3. customThe organic phase was dried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down

Sources & evidence

ORD record
ord-0f91b431f2da4676b32db891dc42d80d
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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