4,6-Dichloropyrimidine → HCID 86663897, compound

HRID 1846435Notes

Reaction equation

HRID 1846435 reaction equation
[NH2:1][C:2]1[CH:12]=[C:11]([CH3:13])[C:5]2[N:6]([CH3:10])[C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[Cl:14][C:15]1[CH:20]=[C:19](Cl)[N:18]=[CH:17][N:16]=1>C(O)CCC>[Cl:14][C:15]1[N:16]=[CH:17][N:18]=[C:19]([NH:1][C:2]2[CH:12]=[C:11]([CH3:13])[C:5]3[N:6]([CH3:10])[C:7](=[O:9])[O:8][C:4]=3[CH:3]=2)[CH:20]=1

Participants

4

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 66978249HCID 66978249, compound

Product 1

HCID 86663897HCID 86663897, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
100 °C

Procedure

300 mg (1.70 mmol) 6-amino-3,4-dimethyl-3H-benzoxazol-2-one, 276 mg (1.90 mmol) 4,6-dichloropyrimidine and 0.77 mL (60 μmol) TEA were combined in 5.0 mL 1-butanol and the mixture was stirred for 1 h at 100° C. The reaction mixture was cooled to RT, evaporated down and the residue was triturated in diethyl ether. The precipitate was washed with water and dried i. vac.

Workup

  1. temperatureThe reaction mixture was cooled to RT
  2. customevaporated down
  3. customthe residue was triturated in diethyl ether
  4. washThe precipitate was washed with water
  5. customdried i

Sources & evidence

ORD record
ord-538e81bd60e046019e71caf19fed6d2d
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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