Acetic Anhydride → HCID 86663901, compound

HRID 1846441Notes

Reaction equation

HRID 1846441 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:19]=[C:18]([CH3:20])[C:12]3[N:13]([CH3:17])[C:14](=[O:16])[O:15][C:11]=3[CH:10]=2)[CH:3]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>O>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]([C:9]2[CH:19]=[C:18]([CH3:20])[C:12]3[N:13]([CH3:17])[C:14](=[O:16])[O:15][C:11]=3[CH:10]=2)[C:21](=[O:23])[CH3:22])[CH:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 86663897HCID 86663897, compound

Product 1

HCID 86663901HCID 86663901, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

100 mg (0.300 mmol) 6-(6-chloro-pyrimidin-4-ylamino)-3,4-dimethyl-3H-benzoxazol-2-one were placed together with 1.00 ml (10.6 mmol) acetic anhydride in a microwave container and stirred for 20 min at 150° C. The reaction mixture was diluted with water and extracted with DCM. The organic phase was separated off, dried and evaporated down. The residue was purified by preparative HPLC. The product-containing fractions were combined and evaporated down.

Workup

  1. extractionextracted with DCM
  2. customThe organic phase was separated off
  3. customdried
  4. customevaporated down
  5. customThe residue was purified by preparative HPLC
  6. customevaporated down

Sources & evidence

ORD record
ord-70a89712debf472581d1bcc1a8e5b54f
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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