4,6-Dichloropyrimidine → HCID 86663902, compound

HRID 1846444Notes

Reaction equation

HRID 1846444 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:10]([CH3:11])=[CH:9][C:8]([NH2:12])=[CH:7][C:5]=2[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18](Cl)[N:17]=[CH:16][N:15]=1>C(O)CCC>[Cl:13][C:14]1[N:15]=[CH:16][N:17]=[C:18]([NH:12][C:8]2[CH:9]=[C:10]([CH3:11])[C:4]3[O:3][C:2]([CH3:1])=[N:6][C:5]=3[CH:7]=2)[CH:19]=1

Participants

4

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 66978002HCID 66978002, compound

Product 1

HCID 86663902HCID 86663902, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
90 °C

Procedure

600 mg (1.90 mmol) 2,7-dimethyl-benzoxazol-5-ylamine, 400 mg (2.70 mmol) 4,6-dichloropyrimidine and 1.50 mL (11.0 mmol) TEA were combined in 8.0 mL 1-butanol and stirred for 2 h at 90° C. The reaction mixture was cooled to RT and purified by preparative HPLC. The product-containing fractions were combined, evaporated down and the residue was triturated with diethyl ether, suction filtered and dried.

Workup

  1. temperatureThe reaction mixture was cooled to RT
  2. custompurified by preparative HPLC
  3. customevaporated down
  4. customthe residue was triturated with diethyl ether, suction
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-72d080e7974a4b9dba2947bc03e9d902
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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