4,6-Dichloropyrimidine → HCID 86663902, compound

Participants

Reaction Conditions

Reaction Steps

600 mg (1.90 mmol) 2,7-dimethyl-benzoxazol-5-ylamine, 400 mg (2.70 mmol) 4,6-dichloropyrimidine and 1.50 mL (11.0 mmol) TEA were combined in 8.0 mL 1-butanol and stirred for 2 h at 90° C. The reaction mixture was cooled to RT and purified by preparative HPLC. The product-containing fractions were combined, evaporated down and the residue was triturated with diethyl ether, suction filtered and dried.

Provenance & Evidence