Formic Acid → 4-methyl-1H-1,3-benzodiazol-6-ol

HRID 1846459Notes

Reaction equation

HRID 1846459 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:10])[CH:5]=[C:6]([CH3:9])[C:7]=1[NH2:8].[CH:11](O)=O>>[CH3:9][C:6]1[C:7]2[N:8]=[CH:11][NH:1][C:2]=2[CH:3]=[C:4]([OH:10])[CH:5]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 199076443,4-Diamino-5-methylphenol

Product 1

HCID 669780884-methyl-1H-1,3-benzodiazol-6-ol

Procedure

276 mg (2.00 mmol) 3,4-diamino-5-methyl-phenol in 3.00 mL formic acid (98%) were refluxed for 1 h. The reaction mixture was then evaporated down and the residue was dried under HV.

Workup

  1. customThe reaction mixture was then evaporated down
  2. customthe residue was dried under HV

Sources & evidence

ORD record
ord-26b10771afe947749abe705570d3f11b
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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