Carbamimidic acid, methyl ester, hydrochloride (1:1) → HCID 178494256, compound

HRID 1846467Notes

Reaction equation

HRID 1846467 reaction equation
C[C:2](C)([C:6]([O-:8])=O)[C:3]([O-:5])=O.[CH3:10][O:11][C:12]([NH2:14])=[NH:13].Cl.C[O-].[Na+]>>[CH3:10][O:11][C:12]1[N:14]=[C:3]([OH:5])[CH:2]=[C:6]([OH:8])[N:13]=1

Participants

4

Reactant 3

HCID 3083899Carbamimidic acid, methyl ester, hydrochloride (1:1)HCID 6946994DimethylmalonatHCID 10942334Sodium Methoxide

Product 1

HCID 178494256HCID 178494256, compound

Procedure

Under a nitrogen atmosphere 3.10 mL (27.0 mmol) dimethylmalonate, 3.00 g (27.1 mmol) o-methylisourea hydrochloride and 15.0 mL (80.8 mmol) sodium methoxide solution (30%) were refluxed for 1.25 h with stirring. The reaction mixture was cooled. The precipitate formed was suction filtered, washed and dried.

Workup

  1. temperatureThe reaction mixture was cooled
  2. customThe precipitate formed
  3. filtrationfiltered
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-2c09af5f9bb9498db3edfc3866b9ceec
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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