Cyclopropanecarboxylic acid → 2-cyclopropyl-4-methyl-1H-benzo[d]imidazol-6-ol

HRID 1846469Notes

Reaction equation

HRID 1846469 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:10])[CH:5]=[C:6]([CH3:9])[C:7]=1[NH2:8].[CH:11]1([C:14](O)=O)[CH2:13][CH2:12]1>>[CH:11]1([C:14]2[NH:1][C:2]3[CH:3]=[C:4]([OH:10])[CH:5]=[C:6]([CH3:9])[C:7]=3[N:8]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 199076443,4-Diamino-5-methylphenol

Product 1

HCID 669781752-cyclopropyl-4-methyl-1H-benzo[d]imidazol-6-ol

Procedure

0.55 g (4.00 mmol) 3,4-diamino-5-methyl-phenol and 1.67 mL (20.00 mmol) cyclopropanecarboxylic acid were stirred for 1 h at 120° C. Then the reaction mixture w evaporated down i.vac. and further reacted as crude product.

Workup

  1. customThen the reaction mixture w evaporated down i.vac
  2. customand further reacted as crude product

Sources & evidence

ORD record
ord-fc3a6a7467e04958b6408727f4cf4d40
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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