Cyclopropanecarboximidamide hydrochloride → HCID 178516636, compound

HRID 1846471Notes

Reaction equation

HRID 1846471 reaction equation
C[C:2](C)([C:6]([O-:8])=O)[C:3]([O-])=[O:4].Cl.[CH:11]1([C:14]([NH2:16])=[NH:15])[CH2:13][CH2:12]1.C[O-].[Na+]>>[CH:11]1([C:14]2[N:16]=[C:6]([OH:8])[CH:2]=[C:3]([OH:4])[N:15]=2)[CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 2781916Cyclopropanecarboximidamide hydrochlorideHCID 6946994DimethylmalonatHCID 10942334Sodium Methoxide

Product 1

HCID 178516636HCID 178516636, compound

Procedure

Under a nitrogen atmosphere 1.50 mL (13.06 mmol) dimethylmalonat, 1.60 g (13.27 mmol) cyclopropanecarboxamidine hydrochloride and 15.0 mL (80.80 mmol) sodium methoxide solution (30%) were refluxed for 1.25 h with stirring. The reaction mixture was slightly acidified and the precipitate formed was suction filtered, washed and dried.

Workup

  1. customthe precipitate formed
  2. filtrationfiltered
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-d075e8bf99e44000b37766e15f75b103
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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