HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 66978230, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 7-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one | HCID 18356852 | — |
| Reactant | HCID 61277540 | HCID 61277540 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66978230 | HCID 66978230 | — |
Reaction Steps
0.69 g (2.51 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 0.66 g (2.48 mmol) 4-chloro-6-(3-methyl-4-nitrophenoxy)pyrimidine and 1.0 mL (5.81 mmol) DIPEA in 1.0 mL DMF were stirred overnight at 40° C. The reaction mixture was mixed with water. The precipitate formed was suction filtered, washed and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952014B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-279169991de64b27bc107dc895f599a8 |
| Source note | uspto-grants-2015_02 |