Water → HCID 66978230, compound

HRID 1846475Notes

Reaction equation

HRID 1846475 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:20]=1.Cl[C:22]1[CH:27]=[C:26]([O:28][C:29]2[CH:34]=[CH:33][C:32]([N+:35]([O-:37])=[O:36])=[C:31]([CH3:38])[CH:30]=2)[N:25]=[CH:24][N:23]=1.CCN(C(C)C)C(C)C.O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][N:17]([C:22]4[CH:27]=[C:26]([O:28][C:29]5[CH:34]=[CH:33][C:32]([N+:35]([O-:37])=[O:36])=[C:31]([CH3:38])[CH:30]=5)[N:25]=[CH:24][N:23]=4)[CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:20]=1

Participants

6

Reactant 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 183568527-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-oneHCID 61277540HCID 61277540, compound

Product 1

HCID 66978230HCID 66978230, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.69 g (2.51 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 0.66 g (2.48 mmol) 4-chloro-6-(3-methyl-4-nitrophenoxy)pyrimidine and 1.0 mL (5.81 mmol) DIPEA in 1.0 mL DMF were stirred overnight at 40° C. The reaction mixture was mixed with water. The precipitate formed was suction filtered, washed and dried.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-279169991de64b27bc107dc895f599a8
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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