Potassium Carbonate → HCID 178432292, compound

HRID 1846477Notes

Reaction equation

HRID 1846477 reaction equation
[Cl:1][C:2]1[C:7]2[NH:8][C:9]([CH3:11])=[N:10][C:6]=2[CH:5]=[C:4]([O:12]C)[CH:3]=1.Cl.N1C=CC=CC=1.C([O-])([O-])=O.[K+].[K+]>>[Cl:1][C:2]1[C:7]2[NH:8][C:9]([CH3:11])=[N:10][C:6]=2[CH:5]=[C:4]([OH:12])[CH:3]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 10176127Pyridinium chlorideHCID 178491884HCID 178491884, compound

Product 1

HCID 178432292HCID 178432292, compound

Procedure

Under a nitrogen atmosphere 0.95 g (4.83 mmol) 7-chloro-5-methoxy-2-methyl-1H-benzo[d]imidazole and 7.0 g (0.06 mol) pyridine hydrochloride were stirred for 15 h at a bath temperature of 180° C. The reaction mixture was poured onto water while still hot and made alkaline with an aqueous K2CO3 solution. The substance was extracted with ethyl acetate and washed with water. The organic phase was separated off, dried and evaporated down i.vac.

Workup

  1. additionThe reaction mixture was poured onto water while still hot and
  2. extractionThe substance was extracted with ethyl acetate
  3. washwashed with water
  4. customThe organic phase was separated off
  5. customdried
  6. customevaporated down i.vac

Sources & evidence

ORD record
ord-3e3513b7f84747d0b2923bcb7c89ac64
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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