Water → HCID 66978308, compound

HRID 1846481Notes

Reaction equation

HRID 1846481 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[NH:7][C:8]([CH3:10])=[N:9][C:5]=2[CH:4]=1.S(Cl)([Cl:16])(=O)=O.O>C(O)(=O)C>[Cl:16][C:4]1[C:5]2[N:9]=[C:8]([CH3:10])[NH:7][C:6]=2[CH:11]=[CH:12][C:3]=1[O:2][CH3:1]

Participants

5

Reactant 3

HCID 962WaterHCID 24648Sulfuryl chloride2×HCID 178488087HCID 178488087, compound

Product 1

HCID 66978308HCID 66978308, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.30 g (8.02 mmol) 5-methoxy-2-methyl-1H-benzo[d]imidazole and 0.70 mL (8.56 mmol) sulphuryl chloride in 30.0 mL acetic acid were stirred for 2 h. Another 0.3 mL sulphuryl chloride were added and the mixture was stirred for a further 2 h. The reaction mixture was mixed with water and evaporated down i.vac. The residue was stirred with DIPE and isopropanol, suction filtered and dried.

Workup

  1. customevaporated down i.vac
  2. stirringThe residue was stirred with DIPE and isopropanol, suction
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-bd4e591718bf4d2bbdddc7f21472eb24
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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