p-Toluenesulfonic acid monohydrate → HCID 178516181, compound

HRID 1846492Notes

Reaction equation

HRID 1846492 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]([CH:13]1[CH2:17][CH2:16][O:15][CH2:14]1)=O.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[Cl:9][C:4]1[C:3]2[NH:10][C:11]([CH:13]3[CH2:17][CH2:16][O:15][CH2:14]3)=[N:1][C:2]=2[CH:7]=[C:6]([OH:8])[CH:5]=1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 66978176N-(2-amino-6-chloro-4-hydroxyphenyl)tetrahydrofuran-3-carboxamide

Product 1

HCID 178516181HCID 178516181, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.10 g (0.39 mmol) N-(2-amino-6-chloro-4-hydroxyphenyl)tetrahydrofuran-3-carboxamide were placed in 20 mL methanol, a spatula tip of p-toluenesulphonic acid monohydrate was added and the mixture was boiled for 2 h. The reaction mixture was evaporated down i.vac. and purified by chromatography. The fractions containing product were combined and evaporated down i.vac.

Workup

  1. customThe reaction mixture was evaporated down i.vac
  2. customand purified by chromatography
  3. additionThe fractions containing product
  4. customevaporated down i.vac

Sources & evidence

ORD record
ord-d47bc832bb53472b83595fbb6a198255
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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