p-Toluenesulfonic acid monohydrate → HCID 178516182, compound

HRID 1846496Notes

Reaction equation

HRID 1846496 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]([CH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)=O.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[Cl:9][C:4]1[C:3]2[NH:10][C:11]([CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[N:1][C:2]=2[CH:7]=[C:6]([OH:8])[CH:5]=1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 66978316N-(2-amino-6-chloro-4-hydroxyphenyl)tetrahydro-2H-pyran-4-carboxamide

Product 1

HCID 178516182HCID 178516182, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.50 g (1.85 mmol) N-(2-amino-6-chloro-4-hydroxyphenyl)tetrahydro-2H-pyran-4-carboxamide were placed in 20 mL methanol, a spatula tip of p-toluenesulphonic acid monohydrate was added and the mixture was boiled overnight. The reaction mixture was evaporated down i.vac. and purified by chromatography. The fractions containing product were combined and evaporated down i.vac.

Workup

  1. customThe reaction mixture was evaporated down i.vac
  2. customand purified by chromatography
  3. additionThe fractions containing product
  4. customevaporated down i.vac

Sources & evidence

ORD record
ord-112702566f484df899a78b5b93de5813
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

Loading…