反应详情

0.50 g (1.85 mmol) N-(2-amino-6-chloro-4-hydroxyphenyl)tetrahydro-2H-pyran-4-carboxamide were placed in 20 mL methanol, a spatula tip of p-toluenesulphonic acid monohydrate was added and the mixture was boiled overnight. The reaction mixture was evaporated down i.vac. and purified by chromatography. The fractions containing product were combined and evaporated down i.vac.

1. customThe reaction mixture was evaporated down i.vac
2. customand purified by chromatography
3. additionThe fractions containing product
4. customevaporated down i.vac