Trifluoroacetic acid → 7-methyl-2-(trifluoromethyl)-1H-benzo[d]imidazol-5-ol

Participants

Reaction Steps

0.20 g (1.45 mmol) 3,4-diamino-5-methylphenol were stirred together with 1 mL (13.07 mmol) trifluoroacetic acid for 1 h at 100° C. The reaction mixture was cooled and purified by chromatography. The fractions containing product were combined and evaporated down i.vac. to leave the aqueous residue. This was neutralised with an aqueous 1M NaOH solution and extracted with ethyl acetate. The organic phase was evaporated down i.vac.

Provenance & Evidence