反应详情

0.20 g (1.45 mmol) 3,4-diamino-5-methylphenol were stirred together with 1 mL (13.07 mmol) trifluoroacetic acid for 1 h at 100° C. The reaction mixture was cooled and purified by chromatography. The fractions containing product were combined and evaporated down i.vac. to leave the aqueous residue. This was neutralised with an aqueous 1M NaOH solution and extracted with ethyl acetate. The organic phase was evaporated down i.vac.

1. temperatureThe reaction mixture was cooled
2. custompurified by chromatography
3. additionThe fractions containing product
4. customevaporated down i.vac
5. customto leave the aqueous residue
6. extractionextracted with ethyl acetate
7. customThe organic phase was evaporated down i.vac