2(3H)-Benzoxazolone, 6-hydroxy- → HCID 86663929, compound

HRID 1846510Notes

Reaction equation

HRID 1846510 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4]([Cl:10])[CH:3]=1.[OH:11][C:12]1[CH:21]=[CH:20][C:15]2[NH:16][C:17](=[O:19])[O:18][C:14]=2[CH:13]=1.[K].[CH3:23]C(C)([O-])C>CN1C(=O)CCC1>[Cl:10][C:4]1[CH:3]=[C:2]([O:11][C:12]2[CH:21]=[C:20]([CH3:23])[C:15]3[NH:16][C:17](=[O:19])[O:18][C:14]=3[CH:13]=2)[C:7]([C:8]#[N:9])=[CH:6][N:5]=1

Participants

5

Reactant 3

HCID 1571672(3H)-Benzoxazolone, 6-hydroxy-HCID 455880804,6-Dichloropyridine-3-carbonitrileHCID 50987170Potassium tertbutoxide

Product 1

HCID 86663929HCID 86663929, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

0.12 g (0.69 mmol) 4,6-dichloro-nicotinonitrile, 0.15 g (0.91 mmol) 6-hydroxy-2-benzoxazolinone and 90 mg (0.80 mmol) potassium-tert.-butoxide in 0.8 mL NMP were stirred for 2 h at 70° C. The reaction mixture was combined with ice water. The precipitate formed was suction filtered and dried.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-875d8bb8ab5e4364ac686f205b6d22df
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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