Acetic Anhydride → N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamide

HRID 1846511Notes

Reaction equation

HRID 1846511 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:13](=[O:15])[CH3:14])=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 678534-Fluoro-2-(trifluoromethyl)aniline

Product 1

HCID 10560920N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamide

Procedure

10.0 g (0.56 mol) 4-fluoro-2-trifluoromethyl-phenylamine were stirred overnight at RT in 40 mL acetic anhydride. The reaction mixture was poured onto 300 g ice water. The precipitate formed was suction filtered, washed with 100 mL water and dried i. vac.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with 100 mL water
  4. customdried i

Sources & evidence

ORD record
ord-9e5bc1e16afa450483b0dd94016e1362
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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