HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 46245031, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 7-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one | HCID 18356852 | — |
| Reactant | HCID 86663921 | HCID 86663921 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 46245031 | HCID 46245031 | — |
Reaction Steps
70 mg (0.25 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 65 mg (0.20 mmol) 7-(6-chloropyrimidin-4-yloxy)-5-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one and 50 μL (0.27 mmol) DIPEA in 2.0 mL DMF were stirred overnight at RT and for 3 h at 40° C. The reaction mixture was combined with water and methanol. The precipitate formed was suction filtered, washed and dried. The filtrate was again suction filtered, washed and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952014B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-b197fea6cbd8404bb2f581b91d01739f |
| Source note | uspto-grants-2015_02 |