Water → HCID 46245031, compound

HRID 1846564Notes

Reaction equation

HRID 1846564 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:20]=1.Cl[C:22]1[N:27]=[CH:26][N:25]=[C:24]([O:28][C:29]2[CH:30]=[C:31]([CH3:40])[C:32]3[NH:37][C:36](=[O:38])[CH2:35][O:34][C:33]=3[CH:39]=2)[CH:23]=1.CCN(C(C)C)C(C)C.O>CN(C=O)C.CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][N:17]([C:22]4[N:27]=[CH:26][N:25]=[C:24]([O:28][C:29]5[CH:30]=[C:31]([CH3:40])[C:32]6[NH:37][C:36](=[O:38])[CH2:35][O:34][C:33]=6[CH:39]=5)[CH:23]=4)[CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:20]=1

Participants

7

Reactant 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 183568527-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-oneHCID 86663921HCID 86663921, compound

Product 1

HCID 46245031HCID 46245031, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

70 mg (0.25 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 65 mg (0.20 mmol) 7-(6-chloropyrimidin-4-yloxy)-5-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one and 50 μL (0.27 mmol) DIPEA in 2.0 mL DMF were stirred overnight at RT and for 3 h at 40° C. The reaction mixture was combined with water and methanol. The precipitate formed was suction filtered, washed and dried. The filtrate was again suction filtered, washed and dried.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed
  4. customdried
  5. filtrationfiltered
  6. washwashed
  7. customdried

Sources & evidence

ORD record
ord-b197fea6cbd8404bb2f581b91d01739f
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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