Trifluoroacetic acid → HCID 44235553, compound

HRID 1846608Notes

Reaction equation

[NH2:1][C@@H:2]1[C:11]([CH3:13])([CH3:12])[C:10]2[CH:9]=[C:8]([C:14]([NH2:16])=[O:15])[CH:7]=[CH:6][C:5]=2[CH2:4][C@H:3]1[O:17][CH3:18].[CH3:19][C:20]([CH3:30])([CH3:29])[CH2:21][C:22]([NH:24][CH2:25][CH2:26][CH:27]=O)=[O:23].C(O)(C(F)(F)F)=O>>[CH3:19][C:20]([CH3:29])([CH3:30])[CH2:21][C:22]([NH:24][CH2:25][CH2:26][CH2:27][NH:1][C@@H:2]1[C:11]([CH3:13])([CH3:12])[C:10]2[CH:9]=[C:8]([C:14]([NH2:16])=[O:15])[CH:7]=[CH:6][C:5]=2[CH2:4][C@H:3]1[O:17][CH3:18])=[O:23]

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 66674620HCID 66674620, compound

HCID 86634828HCID 86634828, compound

Product 1

HCID 44235553HCID 44235553, compound

Procedure

Following the process of Example 11(c) using (6R,7R)-7-amino-6-methoxy-8,8-dimethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid amide and 3,3-dimethyl-N-(3-oxo-propyl)-butyramide the TFA salt of the title compound was prepared. (m/z): [M+H]+ calcd for C23H37N3O3, 404.28; found, 404.8.

Sources & evidence

ORD record: ord-0c561f45cc924a4aa97a39c95c13c622
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08952031B2

Reaction notes

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