Trifluoroacetic acid → HCID 44235554, compound

HRID 1846609Notes

Reaction equation

HRID 1846609 reaction equation
[NH2:1][C@H:2]1[C:11]([CH3:13])([CH3:12])[C:10]2[CH:9]=[C:8]([C:14]([NH2:16])=[O:15])[CH:7]=[CH:6][C:5]=2[CH2:4][C@@H:3]1[O:17][CH3:18].O=[CH:20][CH2:21][CH2:22][NH:23][C:24]([CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)=[O:25].C(O)(C(F)(F)F)=O>>[CH:26]1([C:24]([NH:23][CH2:22][CH2:21][CH2:20][NH:1][C@H:2]2[C:11]([CH3:13])([CH3:12])[C:10]3[CH:9]=[C:8]([C:14]([NH2:16])=[O:15])[CH:7]=[CH:6][C:5]=3[CH2:4][C@@H:3]2[O:17][CH3:18])=[O:25])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 28345101HCID 28345101, compoundHCID 66674617HCID 66674617, compound

Product 1

HCID 44235554HCID 44235554, compound

Procedure

Following the process of Example 11(c) using (6S,7S)-7-amino-6-methoxy-8,8-dimethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid amide and cyclohexanecarboxylic acid (3-oxo-propyl)-amide the TFA salt of the title compound was prepared. (m/z): [M+H]+ calcd for C24H37N3O3, 416.28; found, 416.6.

Sources & evidence

ORD record
ord-720c6ea72db64e5a93696e20fa7509d9
Source dataset
uspto-grants-2015_02
Patent number
US08952031B2

Reaction notes

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