HCID 57960268, compound → HCID 57960164, compound

HRID 1846672Notes

Reaction equation

HRID 1846672 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)[CH2:8][CH2:7]1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])[CH2:10][CH2:11]1)[CH3:2]

Participants

4

Reactant 1

HCID 57960268HCID 57960268, compound

Product 1

HCID 57960164HCID 57960164, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1.85 g (6.33 mmol) of [1-(2-nitro-phenyl)-piperidin-4-yl]-acetic acid ethyl ester in methanol (100 mL) is added 0.65 g (0.61 mmol) of 10% palladium on carbon. The mixture is placed under an atmosphere of hydrogen and shaken at room temperature overnight. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to provide 1.60 g (96.4%) of [1-(2-amino-phenyl)-piperidin-4-yl]-acetic acid ethyl ester as an orange oil.

Workup

  1. filtrationThe mixture is filtered through a pad of diatomaceous earth
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-50d91b7a4e4e4dc2bffc8ca974548e47
Source dataset
uspto-grants-2015_02
Patent number
US08952004B2

Reaction notes

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