HCID 57960268, compound → HCID 57960164, compound

Participants

Reaction Steps

To a solution of 1.85 g (6.33 mmol) of [1-(2-nitro-phenyl)-piperidin-4-yl]-acetic acid ethyl ester in methanol (100 mL) is added 0.65 g (0.61 mmol) of 10% palladium on carbon. The mixture is placed under an atmosphere of hydrogen and shaken at room temperature overnight. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to provide 1.60 g (96.4%) of [1-(2-amino-phenyl)-piperidin-4-yl]-acetic acid ethyl ester as an orange oil.

Provenance & Evidence