HCID 71238060, compound → HCID 68304200, compound

HRID 1846683Notes

Reaction equation

HRID 1846683 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:17]([N+:18]([O-])=O)=[CH:16][CH:15]=[C:14]([S:21]([CH3:24])(=[O:23])=[O:22])[N:13]=2)[CH2:8][CH2:7]1)[CH3:2]>[Pd].C(O)C>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:17]([NH2:18])=[CH:16][CH:15]=[C:14]([S:21]([CH3:24])(=[O:23])=[O:22])[N:13]=2)[CH2:8][CH2:7]1)[CH3:2]

Participants

4

Reactant 1

HCID 71238060HCID 71238060, compound

Product 1

HCID 68304200HCID 68304200, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 0.090 g (0.24 mmol) of (6′-methanesulfonyl-3′-nitro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-acetic acid ethyl ester and 0.015 g (0.014 mmol) of 10% palladium on carbon in ethanol (8 mL) is stirred overnight under an atmosphere of hydrogen. The mixture is passed through a pad of diatomaceous earth and concentrated under reduced pressure to provide 0.076 g (94%) of (3′-amino-6′-methanesulfonyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-acetic acid ethyl ester as a black oil.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c89b641371734a23aa7f5a71f657cf40
Source dataset
uspto-grants-2015_02
Patent number
US08952004B2

Reaction notes

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