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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1846720Generated: November 2, 2026

1-(3-Aminophenyl)pyrrolidin-2-one → 2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(2-oxopyrrolidin-1-yl)phenylamino)pyrimidine-5-carboxamide

https://huagongshe.com/reaction/1846720

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-Aminophenyl)pyrrolidin-2-oneHCID 683956—
Reactant2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[4-(1,2-oxazol-5-yl)anilino]pyrimidine-5-carboxamideHCID 46184612—
Product2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(2-oxopyrrolidin-1-yl)phenylamino)pyrimidine-5-carboxamideHCID 46184366—

Reaction Steps

This compound was synthesised using the synthetic scheme described for the synthesis of compound 122, and using 1-(3-aminophenyl)pyrrolidin-2-one in step 1. MS: 410.5 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08952027B2
Source datasetuspto-grants-2015_02
ORD IDord-bb397d5c3bef4720b8134c6ad38de29c
Source noteuspto-grants-2015_02