HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-((3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)oxy)cyclobutanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl (3-((3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)oxy)cyclobutyl)carbamate | HCID 58548637 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-((3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)oxy)cyclobutanamine hydrochloride | HCID 67478736 | 95% |
Reaction Steps
To tert-butyl (3-((3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)oxy)cyclobutyl)carbamate (348 mg, 1 mmol) was added 4 M HCl in MeOH (100 mL). The solution was stirred at RT for 2 hours. The solvent was removed under reduced pressure to give 3-((3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)oxy)cyclobutanamine hydrochloride (248 mg, 0.95 mmol, yield 95%). ESI-MS (M+1): 249 calc. for C19H28N2O4 248.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952037B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-99c69153b9f94f69bf06cc19134abb7a |
| Source note | uspto-grants-2015_02 |