HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-((3-Bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl (3-((3-bromopyridin-2-yl)oxy)cyclobutyl)carbamate | HCID 58548513 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-((3-Bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride | HCID 67478726 | 95% |
Reaction Steps
To tert-butyl (3-((3-bromopyridin-2-yl)oxy)cyclobutyl)carbamate (see PREPARATION 7B; 342 mg, 1 mmol) was added 4 M HCl in MeOH (50 mL). The solution was stirred at RT for 2 hours. The solvent was removed under reduced pressure to give 3-((3-bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride (223 mg, 0.95 mmol, yield 95%). ESI-MS (M+1): 243 calc. for C9H11BrN2O 242.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952037B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-edc6690e987a4e77b2c19b9cd03ebe42 |
| Source note | uspto-grants-2015_02 |