Methanesulfonic Acid → HCID 58119003, compound

HRID 1846944Notes

Reaction equation

HRID 1846944 reaction equation
C([O:8][CH2:9][C:10]1[N:15]2[C:16]([C:19]([F:22])([F:21])[F:20])=[N:17][N:18]=[C:14]2[CH:13]=[CH:12][C:11]=1[Cl:23])C1C=CC=CC=1.CS(O)(=O)=O>>[Cl:23][C:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([C:19]([F:20])([F:21])[F:22])=[N:17][N:18]=2)[C:10]=1[CH2:9][OH:8]

Participants

3

Reactant 2

HCID 6395Methanesulfonic AcidHCID 66849761HCID 66849761, compound

Product 1

HCID 58119003HCID 58119003, compound

Procedure

To a solution of 5-(benzyloxymethyl)-6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine, prepared as described in Step 4 (700 mg, 2.1 mmol) was added methanesulfonic acid (2 mL, 70% in water) and the reaction was heated to reflux overnight. The reaction was concentrated and the residue purified by flash chromatography to yield (6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-5-yl)methanol.

Workup

  1. temperaturethe reaction was heated
  2. temperatureto reflux overnight
  3. concentrationThe reaction was concentrated
  4. customthe residue purified by flash chromatography

Sources & evidence

ORD record
ord-5fc2e12b0bfc43e2b9b14f13798ea68e
Source dataset
uspto-grants-2015_02
Patent number
US08952034B2

Reaction notes

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