反应详情

温度

100 °C

(3S,5R,6R)-3-Allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one (32 g, 81 mmol, Example 4, Step E) was combined with (S)-2-amino-2-cyclopropylethanol (26.7 g, 265 mmol) and the suspension was heated at 100° C. overnight. The reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with 1 N hydrochloric acid (2×), water, and brine. The organic layer was dried over magnesium sulfate and concentrated under vacuum to provide the title compound as a white solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. washwashed with 1 N hydrochloric acid (2×), water, and brine
3. dry with materialThe organic layer was dried over magnesium sulfate
4. concentrationconcentrated under vacuum