反应详情

A mixture of 6-amino-2H-1,4-benzoxazin-3(4H)-one (4.93 g, 30.0 mmol), itaconic acid (4.06 g, 31.2 mmol) and water (80 ml) was heated under reflux overnight. The reaction solution was cooled, and the insoluble material was collected by filtration and washed with water and diethyl ether. The filtrate was dried at 50° C. under reduced pressure to yield 7.92 g (96%) of the title compound in the form of a brownish solid.

1. temperaturewas heated
2. temperatureunder reflux overnight
3. temperatureThe reaction solution was cooled
4. filtrationthe insoluble material was collected by filtration
5. washwashed with water and diethyl ether
6. customThe filtrate was dried at 50° C. under reduced pressure