反应详情

To a solution of 6-[(4S)-4-(azidomethyl)-2-oxopyrrolidin-1-yl]-2H-1,4-benzoxazin-3(4H)-one (430 mg, 1.50 mmol) in methanol (40 ml)/tetrahydrofuran (40 ml) was added 10% palladium on carbon catalyst (53% aqueous, 100 mg) at room temperature and the mixture was stirred at the same temperature for 2 hours under a hydrogen atmosphere. The catalyst was removed by filtration and the residue obtained by concentrating the filtrate was purified by silica gel column chromatography (NH silica gel, dichloromethane/methanol) to yield 336 mg (86%) of the title compound in the form of a light yellow amorphous solid.

1. customThe catalyst was removed by filtration
2. customthe residue obtained
3. concentrationby concentrating the filtrate
4. customwas purified by silica gel column chromatography (NH silica gel, dichloromethane/methanol)