反应详情

In methanol (250 ml) was dissolved (2R)-2-hydroxy-4-(6-methoxy-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)butyl 4-methylbenzensulfonate (4.30 g, 10.25 mmol), potassium carbonate (1.70 g, 12.30 mmol) was added thereto at room temperature and the mixture was stirred for 4 hours. The reaction solution was concentrated under reduced pressure and the residue was diluted with chloroform and washed with water. After drying the resultant over anhydrous sodium sulfate, the solvent was removed under reduced pressure and the obtained residue was purified by silica gel column chromatography (chloroform/methanol) to yield 2.62 g (quantitative) of the title compound in the form of a yellowish solid.

1. additionwas added
2. concentrationThe reaction solution was concentrated under reduced pressure
3. additionthe residue was diluted with chloroform
4. washwashed with water
5. dry with materialAfter drying the resultant over anhydrous sodium sulfate
6. customthe solvent was removed under reduced pressure
7. customthe obtained residue was purified by silica gel column chromatography (chloroform/methanol)