Benzyl 4-(3,3-dimethoxypropyl)-6-methoxy-3-oxo-3,4-dihydroquinoxalin-1(2H)-carboxylate → 1-(3,3-Dimethoxypropyl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)one

HRID 1847081노트

반응식

HRID 1847081 반응식
[CH3:1][O:2][CH:3]([O:29][CH3:30])[CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[N:9](C(OCC2C=CC=CC=2)=O)[CH2:8][C:7]1=[O:28]>CO.[Pd]>[CH3:30][O:29][CH:3]([O:2][CH3:1])[CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[NH:9][CH2:8][C:7]1=[O:28]

참가 물질

4

반응물 1

HCID 86725004Benzyl 4-(3,3-dimethoxypropyl)-6-methoxy-3-oxo-3,4-dihydroquinoxalin-1(2H)-carboxylate

생성물 1

HCID 867250051-(3,3-Dimethoxypropyl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)one수율 77%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Benzyl 4-(3,3-dimethoxypropyl)-6-methoxy-3-oxo-3,4-dihydroquinoxalin-1(2H)-carboxylate (386 mg, 0.931 mmol) was dissolved in methanol (5 ml), 10% palladium on carbon (50% wet, 200 mg) was added thereto and the mixture was stirred at room temperature for 4 hours under a hydrogen gas atmosphere. After removing the catalyst by filtration using celite, the filtrate was concentrated under reduced pressure to yield 201 mg (77%) of a crude product of the title compound in the form of a yellow oil.

후처리

  1. customAfter removing the catalyst
  2. filtrationby filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f2b4eca11afb4477a3d4cb68f5770eac
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952010B2

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