反应详情

Compound 95 (7.6 mg, 0.019 mmol) obtained in Example 67 was dissolved in allylbromide (0.5 mL), and silver oxide (986 mg, 4.25 mmol) was added thereto, followed by stirring under light shading at room temperature for 12 hours. Silver oxide was separated by filtration, the filtrate was concentrated, and then the residue was purified by silica gel column chromatography (33% ethyl acetate/n-hexane) to obtain the title compound (4.2 mg, 48%).

1. customSilver oxide was separated by filtration
2. concentrationthe filtrate was concentrated
3. customthe residue was purified by silica gel column chromatography (33% ethyl acetate/n-hexane)