反应详情

To 1000 ml of water in the RBF charge 192 gm of (3.0 eq) of sodium hydroxide under cooling followed by 200 gm of Taurine and dissolve it until clear solution is obtained. Cool to 0° C. to 5° C., and Charge 50% CBZ-Cl in toluene at 0° C. to 5° C. After completion of addition, maintain at room temperature for 14 h. Separate the toluene layer and wash the aqueous layer with 2×200 ml of ethyl acetate. Add slowly 27 gm of sodium hydroxide in 60 ml of water to the aqueous layer and adjust pH to 12-14. Cool to 0° C. to 5° C. and a white solid separates from the solution. Filter the solid and dry the solid at 60-70° C. Weight of the solid: 320 g

1. temperatureunder cooling
2. dissolutiondissolve it until clear solution
3. customis obtained
4. temperatureCool to 0° C. to 5° C.
5. additionAfter completion of addition
6. customSeparate the toluene layer
7. washwash the aqueous layer with 2×200 ml of ethyl acetate
8. additionAdd slowly 27 gm of sodium hydroxide in 60 ml of water to the aqueous layer
9. temperatureCool to 0° C. to 5° C.
10. filtrationFilter the solid
11. customdry the solid at 60-70° C