Trimethylsilylacetylene → HCID 136344058, compound

HRID 1847275Notes

Reaction equation

[CH2:1]([O:5][C:6]([C:8]1[C:9]([OH:19])=[C:10]2[C:17]([CH3:18])=[N:16][S:15][C:11]2=[C:12](Br)[N:13]=1)=[O:7])[CH2:2][CH2:3][CH3:4].[CH3:20][Si:21]([C:24]#[CH:25])([CH3:23])[CH3:22]>>[CH2:1]([O:5][C:6]([C:8]1[C:9]([OH:19])=[C:10]2[C:17]([CH3:18])=[N:16][S:15][C:11]2=[C:12]([C:25]#[C:24][Si:21]([CH3:23])([CH3:22])[CH3:20])[N:13]=1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 66111Trimethylsilylacetylene

HCID 136343979HCID 136343979, compound

Product 1

HCID 136344058HCID 136344058, compound

Procedure

The title compound was synthesized in analogy Example 6 from 7-bromo-4-hydroxy-3-methyl-isothiazolo[5,4-c]pyridine-5-carboxylic acid butyl ester and trimethylsilylacetylene: MS (m/z) 363.2 (M+1).

Sources & evidence

ORD record: ord-f73aa8458d504813a9f8bb549b4dbc50
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08952160B2

Reaction notes

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