HCID 86681241, compound → HCID 86681247, compound

HRID 1848273Notes

Reaction equation

HRID 1848273 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:12][C:13]2[CH:23]=[CH:22][C:16]3[N:17]=[C:18]([S:20][CH3:21])[S:19][C:15]=3[CH:14]=2)[CH:10]=O)=[C:5]([N+:24]([O-])=O)[CH:4]=1)#[N:2].IC1C=CC(N(CC2C=CC3N=C(SC)SC=3C=2)C=O)=C([N+]([O-])=O)C=1>>[CH3:21][S:20][C:18]1[S:19][C:15]2[CH:14]=[C:13]([CH2:12][N:9]3[C:6]4[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][C:5]=4[N:24]=[CH:10]3)[CH:23]=[CH:22][C:16]=2[N:17]=1

Participants

3

Reactant 2

HCID 86681241HCID 86681241, compoundHCID 86681248HCID 86681248, compound

Product 1

HCID 86681247HCID 86681247, compound

Procedure

1-((2-(Methylthio)benzo[d]thiazol-6-yl)methyl)-1H-benzo[d]imidazole-5-carbonitrile was synthesized as a white solid (694 mg, 86%) using a procedure analogous to that described in Step 3 of Example 232, substituting N-(4-cyano-2-nitrophenyl)-N-((2-(methylthio)benzo[d]thiazol-6-yl)methyl)formamide from the previous step for N-(4-iodo-2-nitrophenyl)-N-((2-(methylthio)benzo[d]thiazol-6-yl)methyl)formamide used in Example 232. LCMS (ESI) m/z 337 (M+H)+.

Sources & evidence

ORD record
ord-136d2439f7f241d4bef5909c0d9a76c2
Source dataset
uspto-grants-2015_02
Patent number
US08952058B2

Reaction notes

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