Potassium Carbonate → HCID 68612341, compound

HRID 1848285Notes

Reaction equation

HRID 1848285 reaction equation
[C:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH2:10])=[O:9])=[C:6]([CH3:13])[CH:5]=1)(=[O:3])[CH3:2].[Cl:14][C:15]1[CH:16]=[C:17]([C:22](=[O:27])[C:23]([F:26])([F:25])[F:24])[CH:18]=[C:19]([Cl:21])[CH:20]=1.C(=O)([O-])[O-].[K+].[K+]>C([O-])(=O)CCCCCCCCCCC.[Na+].O>[Cl:14][C:15]1[CH:16]=[C:17]([C:22]([OH:27])([C:23]([F:24])([F:25])[F:26])[CH2:2][C:1]([C:4]2[CH:12]=[CH:11][C:7]([C:8]([NH2:10])=[O:9])=[C:6]([CH3:13])[CH:5]=2)=[O:3])[CH:18]=[C:19]([Cl:21])[CH:20]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 27582311-(3,5-Dichlorophenyl)-2,2,2-trifluoroethan-1-oneHCID 53825865HCID 53825865, compound

Product 1

HCID 68612341HCID 68612341, compoundYield 85.5%

Reagents, catalysts & solvents 2

HCID 2735067Sodium LaurateCatalystHCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

0.35 g of 4-acetyl-2-methylbenzoic acid amide, 0.49 g of 3′,5′-dichloro-2,2,2-trifluoroacetophenone, 2.96 g of distilled water, 83 mg of potassium carbonate and 13 mg of sodium laurate were fed and the mixture was stirred for 5.5 hours at 70° C. The mixture was left to cool to room temperature and the slurry-state reaction solution was filtered under reduced pressure, and the solid was washed with a small amount of distilled water. 0.71 g of 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-2-methylbenzoic acid amide as a flesh color solid was obtained by drying under reduced pressure.

Workup

  1. waitThe mixture was left
  2. temperatureto cool to room temperature
  3. customthe slurry-state reaction solution
  4. filtrationwas filtered under reduced pressure
  5. washthe solid was washed with a small amount of distilled water

Sources & evidence

ORD record
ord-6d09fe403f534d3782e5dcc647b602ab
Source dataset
uspto-grants-2015_02
Patent number
US08952175B2

Reaction notes

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