Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate → 2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-3-one

Participants

Role	Name	HCID	Charge
Reactant	Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate	HCID 10015184	—
Reactant	4-bromo-5H-furan-2-one	HCID 11789536	—
Reactant	2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,9-diazaspiro[5.5]undecan-1-one	HCID 86709455	—
Product	2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-3-one	HCID 86709454	—

Reaction Steps

The title compound was prepared from 3-oxo-2,8-diaza-spiro[4,5]decane-8-carboxylic acid tert-butyl ester and 4-bromofuran-2(5H)-one in two steps in an analogous fashion to that described for 2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,9-diazaspiro[5.5]undecan-1-one (I-18) above. LC/MS: [(M+1)]+=237

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08952166B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-887dfc9b823048529082dfedcc64ab30
Source note	uspto-grants-2015_02