Hydrogen Bromide → HCID 67932016, compound

HRID 1848452Notes

Reaction equation

HRID 1848452 reaction equation
BrC[C:3](=[O:12])[CH:4]([CH2:10][CH3:11])[C:5]([O:7][CH2:8]C)=[O:6].Br>>[CH2:10]([C:4]1[C:5](=[O:6])[O:7][CH2:8][C:3]=1[OH:12])[CH3:11]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 15758244HCID 15758244, compound

Product 1

HCID 67932016HCID 67932016, compound

Conditions

Temperature
100 °C

Procedure

A mixture of ethyl 4-bromo-2-ethyl-3-oxobutanoate and hydrogen bromide (48%, 0.037 mL, 0.327 mmol) was heated at 100° C. for 20 h. After cooling to rt, the solid was collected by filtration followed by diethyl ether washing to give 3-ethyl-4-hydroxyfuran-2(5H)-one. LC/MS: (M+1)+: 129.05.

Workup

  1. temperatureAfter cooling to rt
  2. filtrationthe solid was collected by filtration

Sources & evidence

ORD record
ord-bf3b184135b642aaaaac160e1058b24f
Source dataset
uspto-grants-2015_02
Patent number
US08952166B2

Reaction notes

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