Trifluoroacetic acid → 2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]dec-3-en-1-one

HRID 1848489Notes

Reaction equation

HRID 1848489 reaction equation
[O:1]=[C:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH:5]=[CH:4][N:3]1[C:19]1[CH2:20][O:21][C:22](=[O:24])[CH:23]=1.C(O)(C(F)(F)F)=O>>[O:24]=[C:22]1[O:21][CH2:20][C:19]([N:3]2[CH:4]=[CH:5][C:6]3([CH2:7][CH2:8][NH:9][CH2:10][CH2:11]3)[C:2]2=[O:1])=[CH:23]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86709499tert-Butyl 1-oxo-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]dec-3-ene-8-carboxylate

Product 1

HCID 867095002-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]dec-3-en-1-one

Procedure

The title compound was prepared from tert-Butyl 1-oxo-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]dec-3-ene-8-carboxylate using TFA in an analogous fashion to that described for 1-19, Step B. LC/MS: [(M+1)]+=235

Sources & evidence

ORD record
ord-9490b65a31c84700ac80aa6f91cf699b
Source dataset
uspto-grants-2015_02
Patent number
US08952166B2

Reaction notes

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